Artículos de revistas
Asymmetrical proliferative pattern loss linked to cyclin D1 overexpression during malignant transformation of the lip epithelium
Fecha
2016-08-01Registro en:
Journal Of The European Academy Of Dermatology And Venereology. Hoboken: Wiley-blackwell, v. 30, n. 8, p. 1315-1320, 2016.
0926-9959
10.1111/jdv.13671
WOS:000382841200009
Autor
Universidade de São Paulo (USP)
Univ Granada
Granada Complejo Hosp San Cecilio
Universidade Estadual Paulista (Unesp)
Institución
Resumen
BackgroundThere is inadequate knowledge on the involvement of oncogenic mechanisms linked to the cyclin (CCND1) gene in lip squamous cell carcinoma (LSCC). ObjectiveThe aim of this study was to analyse the implication of cyclin D1 in the malignant transformation of lip lesions. MethodsWe immunohistochemically studied 45 actinic cheilitis cases (15 mild dysplasia, 15 moderate dysplasia, 15 severe dysplasia/carcinoma in situ), 30 LSCC cases with adjacent non-tumour epithelium and 15 normal oral epithelium samples for detection of cyclin D1, -catenin and Ki-67. ResultsCyclin D1 and Ki-67 expressions were significantly increased in the basal layer of premalignant epithelia and peripheral layers of tumour nests vs. controls. Premalignant epithelia had lost their asymmetrical proliferative pattern. ConclusionLip carcinogenesis was associated with loss of the asymmetrical proliferative pattern, a preventive mechanism against lip oncogenesis, and with cyclin D1 overexpression.