Artículos de revistas
Human platelets antigens influence the viral load of platelets after the interaction of the platelets with HCV and HIV in vitro
Fecha
2016-07-01Registro en:
Revista Da Sociedade Brasileira De Medicina Tropical. Brasilia: Soc Brasileira Medicina Tropical, v. 49, n. 4, p. 491-493, 2016.
0037-8682
10.1590/0037-8682-0105-2016
S0037-86822016000400491
WOS:000382457200015
S0037-86822016000400491.pdf
3587895085226224
5020559826568182
0000-0001-9200-5391
0000-0003-1948-5071
Autor
Universidade Estadual Paulista (Unesp)
Institución
Resumen
Introduction: In this study, we evaluated hepatitis C virus (HCV) and human immunodeficiency virus (HIV) - platelet interactions in vitro as well as human platelets antigen (HPA) polymorphisms. Methods: Platelets were obtained from 100 healthy HPA-genotyped volunteer donors and incubated with HIV or HCV. The viral load after in vitro exposure was detected. Results: The viral load in the platelets after exposure to the virus was higher in the HIV exposure than in the HCV exposure. Conclusions: HIV-platelet ligation could be more efficient than HCV-platelet interaction. Further, the HPA-1b allele seems to influence the interaction of platelets with HCV.