Artículos de revistas
Butyrylcholinesterase as a marker of inflammation and liver injury in the acute and subclinical phases of canine ehrlichiosis
Fecha
2015-12-01Registro en:
Comparative Immunology Microbiology And Infectious Diseases. Oxford: Elsevier Sci Ltd, v. 43, p. 16-21, 2015.
0147-9571
10.1016/j.cimid.2015.09.005
WOS:000368353900003
WOS000368353900003.pdf
Autor
Universidade Federal de Sergipe (UFS)
Universidade Estadual Paulista (Unesp)
Univ Franca
Univ Fed Rio Grande do Sul
Univ Luteranda Brasil ULBRA
Univ Estado Santa Catarina UDESC
Institución
Resumen
The aim of this study was to evaluate the role of butyrylcholinesterase (BChE) as a marker of inflammation and liver injury in the acute and subclinical phases of canine ehrlichiosis. Forty-two serum samples of dogs naturally infected with Ehrlichia canis were used, of which 24 were from animals with the acute phase of the disease and 18 with subclinical disease. In addition, sera from 17 healthy dogs were used as negative controls. The hematocrit, BChE activity, hepatic injury (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)), nitric oxide, and cytokines levels were evaluated. The BChE activity was significantly elevated (P < 0.05) in dogs with the acute phase of the disease when compared to healthy animals. However, there was a reduction on BChE activity on dogs with subclinical disease compared to the other two groups. AST and ALT levels were significantly higher (P < 0.05) in the acute phase, as well as the inflammatory mediators (NO chi, TNF-alpha, INF-gamma, IL-4, IL-6) when compared to the control group. On the other hand, IL-10 levels were lower in the acute phase. Based on these results, we are able to conclude that the acute infection caused by E. canis in dogs leads to an increase on seric BChE activity and some inflammatory mediators. Therefore, this enzyme might be used as a marker of acute inflammatory response in dogs naturally infected by this bacterium. (C) 2015 Elsevier Ltd. All rights reserved.