Artículos de revistas
The universal growth rate behavior and regime transition in adherent cell colonies
Fecha
2015-12-21Registro en:
Journal Of Theoretical Biology. London: Academic Press Ltd- Elsevier Science Ltd, v. 387, p. 181-188, 2015.
0022-5193
10.1016/j.jtbi.2015.09.035
WOS:000365245800019
WOS000365245800019.pdf
Autor
Universidade de São Paulo (USP)
Universidade Estadual Paulista (Unesp)
Institución
Resumen
In this work, we used five cell lineages, cultivated in vitro, to show they follow a common functional form to the growth rate: a sigmoidal curve, suggesting that competition and cooperation (usual mechanisms for systems with this behavior) might be present. Both theoretical and experimental investigations, on the causes of this behavior, are challenging for the research field; since the sigmoidal form to the growth rate seems to absorb important properties of such systems, e.g., cell deformation and statistical interactions. We shed some light on this subject by showing how cell spreading affects the radius behavior of the growing colonies. Doing numerical time derivatives of the experimental data, we obtained the growth rates. Using reduced variables for the time and rates, we obtained the collapse of all colonies growth rates onto one curve with sigmoidal shape. This suggests a universal-type behavior, with regime transition related to a morphological transition of adherent cell colonies. (C) 2015 Elsevier Ltd. All rights reserved.