Synthesis of Analogues of Thyroid Hormones: Nuclear Receptor Modulators

Artículos de revistas

Fecha

2015-07-01

Registro en:

Orbital-the Electronic Journal Of Chemistry. Campo Grande: Univ Federal Mato Grosso Sul, Dept Quimica, v. 7, n. 3, p. 282-291, 2015.

1984-6428

http://hdl.handle.net/11449/160636

10.17807/orbital.v7i3.739

WOS:000219762300011

WOS000219762300011.pdf

7989837727910759

0000-0002-5240-4870

Autor

Universidade Federal do ABC (UFABC)

Universidade de São Paulo (USP)

Universidade Estadual Paulista (Unesp)

Institución

Universidade Estadual Paulista (Brasil)

Resumen

Thyroid hormones are essential for the development and differentiation of all cells of the human body. This work reports the synthesis of some synthetic structural analogues of thyroid hormones, which may be modulators of the thyroid hormone receptor. The known compounds GC-1 (Sobetirome) and CG-24 were successfully prepared and two novel analogous molecules were also synthesized by a new and efficient synthetic methodology.

Materias

thyroid hormones

nuclear receptor

ligands

synthesis

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