Artículos de revistas
Stability study and degradation kinetics of ceftazidime in pharmaceutical preparations
Fecha
2012Registro en:
Advances in Analytical Chemistry, v. 2, n. 1, p. 1-5, 2012.
2163-2847
10.5923/j.aac.20120201.01
9048202968088646
9881720291571774
Autor
Universidade Estadual Paulista (Unesp)
Institución
Resumen
Stability study of ceftazidime was realized in order to investigate kinetics of degradation of this drug both in powder for injection and reconstituted sample. Ceftazidime was submitted to conditions of accelerated thermal degradation and photodegradation. Analyses of the degraded samples were performed by microbiological assay and decomposition reactions could be described by zero-order and second-order kinetics. Results obtained confirm the reliability of the microbiological assay for determination of ceftazidime by the presence of its degradation products. The present study revealed thermal and photo lability of the drug, especially as reconstituted sample, and protection is recommended during storage and handling.