Artículos de revistas
Chromosome aberrations in lymphocyte cultures from paracoccidioidomycosis patients
Date
1994-07-21Registration in:
Journal of Medical and Veterinary Mycology, v. 32, n. 3, p. 199-203, 1994.
0268-1218
10.1080/02681219480000261
WOS:A1994NU15600005
2-s2.0-0028064743
8789480458377552
Author
Universidade Estadual Paulista (Unesp)
Institutions
Abstract
Blood cell lymphocyte chromosomes from untreated (UT) and clinically-cured (CC) patients with paracoccidioidomycosis and from healthy (control) people (CO) were studied. The frequency of aneuploid cells in the UT patients was higher than in the CC and CO individuals. The frequency of metaphase cells with premature centromere division was significantly higher in the UT than in the CC and CO group. No structural aberration and no statistically significant difference in the frequency of polyploidy was observed in the three groups studied. Our findings are indicative of an aneugenic (aneuploidy-inducing) action of infection by Paracoccidioides brasiliensis.