Artículos de revistas
Interleukin 10 and tumor necrosis factor-alpha in pregnancy: aspects of interest in clinical obstetrics
Fecha
2012Registro en:
Isrn Obstetrics And Gynecology, v. 2012, 2012.
2090-4444
10.5402/2012/230742
PMC3302063.pdf
6758680388835078
22462002
PMC3302063
0000-0002-9227-832X
Autor
Universidade Estadual Paulista (Unesp)
Institución
Resumen
The purpose of this study was to review the literature regarding the action of the cytokines interleukin 10 (IL-10) and tumor necrosis factor-alpha (TNF-α) in pregnancy and to emphasize the factors that are of interest to clinical obstetrics. The literature highlights several actions of IL-10 and TNF-α during pregnancy. The actions of these cytokines seem to be antagonistic and dependent on the balance between them, which is orchestrated by the specific immunosuppressive action of IL-10. TNF-α has a characteristic inflammatory action, and it is an additional diabetogenic factor in pregnancy. The loss of the control of the production of these cytokines, with increase of TNF-α, is related to the risk for developing obstetric complications, particularly recurrent fetal loss, gestational diabetes mellitus, hypertensive syndromes, and fetal growth restriction. However, study results are controversial and are not clearly defined. These issues are attributed to the heterogeneity of the studies, particularly regarding their sample sizes and sources, the evaluation methods, and the multiplicity of factors and conditions that influence cytokine production. These questions are fundamental and should be addressed in future investigations to obtain more consistent results that can be applied to obstetric practice.