Thermal stability and thermal decomposition of the antihypertensive drug amlodipine besylate

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-10-22T07:20:59Z
dc.date.available2015-10-22T07:20:59Z
dc.date.created2015-10-22T07:20:59Z
dc.date.issued2015-04-01
dc.identifierJournal Of Thermal Analysis And Calorimetry, v. 120, n. 1, p. 889-892, 2015.
dc.identifier1388-6150
dc.identifierhttp://hdl.handle.net/11449/129850
dc.identifier10.1007/s10973-014-3992-z
dc.identifierWOS:000352139800097
dc.description.abstractSimultaneous thermogravimetry and differential scanning calorimetry (TG-DSC), differential scanning calorimetry (DSC) and coupled thermogravimetry coupled to infrared spectroscopy (TG-FTIR) were used to study the antihypertensive drug amlodipine besylate. The TG-DSC curves provided information concerning the thermal stability and the decomposition steps of the compound, while the DSC technique allowed us to confirm that the melting occurs concomitantly with the decomposition of the sample. By using the TG coupled to FTIR coupled techniques, it was possible to identify ammonia and methanol and CO2 as compounds released during the thermal degradation of the drug.
dc.languageeng
dc.publisherSpringer
dc.relationJournal Of Thermal Analysis And Calorimetry
dc.relation2.209
dc.relation0,587
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAmlodipine besylate
dc.subjectThermal behavior
dc.subjectTG-FTIR
dc.titleThermal stability and thermal decomposition of the antihypertensive drug amlodipine besylate
dc.typeArtículos de revistas


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