Artículos de revistas
Ribifolin, an orbitide from jatropha ribifolia, and its potential antimalarial activity
Fecha
2015-03-01Registro en:
Journal Of Natural Products. Washington: Amer Chemical Soc, v. 78, n. 3, p. 374-380, 2015.
0163-3864
10.1021/np5007668
WOS:000352033900006
9424346762460416
4484083685251673
0000-0002-4767-0904
Autor
Universidade Estadual Paulista (Unesp)
Univ Manchester
Univ Queensland
Med Univ Vienna
Universidade de São Paulo (USP)
Universidade Federal do Rio Grande do Sul (UFRGS)
Universidade Federal da Paraíba (UFPB)
Institución
Resumen
A new orbitide named ribifolin was isolated and characterized from Jatropha ribifolia using mass spectrometry, NMR spectroscopy, quantitative amino acid analysis, molecular dynamics/simulated annealing, and Raman optical activity measurements and calculations. Ribifolin (1) and its linear form (1a) were synthesized by solid-phase peptide synthesis, followed by evaluation of its antiplasmodial and cytotoxicity activities. Compound 1 was moderately effective (IC50 = 42 mu M) against the Plasmodium falciparum strain 3D7.