Artículos de revistas
Capacitive DNA detection driven by electronic charge fluctuations in a graphene nanopore
Fecha
2015-03-09Registro en:
Physical Review Applied, v. 3, n. 3, p. 1-7, 2015.
2331-7019
10.1103/PhysRevApplied.3.034003
WOS:000350625900001
4785631459929035
0000-0001-8874-6947
Autor
Universidade Estadual Paulista (Unesp)
Universidade Federal do ABC (UFABC)
Inst Catala Nanociencia & Nanotecnol
CSIC
Uppsala Univ
Institución
Resumen
The advent of parallelized automated methods for rapid whole-genome analysis has led to an exponential drop in costs, thus greatly accelerating biomedical research and discovery. Third-generation sequencing techniques, which would utilize the characteristic electrical conductance of the four different nucleotides, could facilitate longer base read lengths and an even lower price per genome. In this work, we propose and apply a quantum-classical hybrid methodology to quantitatively determine the influence of the solvent on the dynamics of DNA and the resulting electron transport properties of a prototypic sequencing device utilizing a graphene nanopore through which the nucleic-acid chain is threaded. Our results show that charge fluctuations in the nucleotides are responsible for characteristic conductance modulations in this system, which can be regarded as a field-effect transistor tuned by the dynamic aqueous environment.