Artículos de revistas
Cord blood cytokine levels in focal early-onset neonatal infection after preterm premature rupture of membranes
Fecha
2013-11-01Registro en:
Turkish Journal Of Pediatrics. Ankara: Turkish J Pediatrics, v. 55, n. 6, p. 598-605, 2013.
0041-4301
WOS:000341415700005
8510423269540465
2559637400719543
8499437381595614
1197755531108177
4940791909535775
1446883241749717
0000-0001-5478-4996
0000-0003-1380-7527
Autor
Universidade Estadual Paulista (Unesp)
Institución
Resumen
This study aimed to evaluate the levels of pro-and anti-inflammatory cytokines in umbilical cord blood of preterm neonates who developed focal early-onset infection (EOI) after preterm premature rupture of membranes (PPROM). This is a prospective study conducted on 46 preterm infants from mothers with PPROM. The cytokines were measure by flow cytometry. Newborns were classified into two groups as focal EOI (n=19) and non-infected (n=27). Interleukin (IL)-6 and IL-8 levels were higher, whereas IL-10 and IL-12 p70 levels were lower in the EOI when compared to the non-infected group. The best combination of cytokines was IL-6+IL-8, with a diagnostic accuracy of 0.97. Focal EOI after PPROM is associated with increased levels of IL-6 and IL-8 and diminished IL-10 and IL-12 in the cord blood of preterm infants. Combined assessment of IL-6 and IL-8 in cord blood may provide an additional tool for identifying preterm infants who develop EOI after PPROM.