Artículos de revistas
Gastroprotective effects (in rodents) of a flavonoid rich fraction obtained from Syngonanthus macrolepsis
Fecha
2014-03-01Registro en:
Journal Of Pharmacy And Pharmacology. Hoboken: Wiley-blackwell, v. 66, n. 3, p. 445-452, 2014.
0022-3573
10.1111/jphp.12175
WOS:000331357000012
3538253640602977
3814504901386844
0000-0002-8645-3777
0000-0003-3032-2556
Autor
Universidade Federal da Paraíba (UFPB)
Universidade Estadual de Campinas (UNICAMP)
Universidade Estadual Paulista (Unesp)
Institución
Resumen
Objectives: Syngonanthus macrolepis, popularly known in Brazil as sempre-vivas', is a plant from the family Eriocaulaceae, it is found in the states of Minas Gerais and Bahia. The species contains a variety of constituents, including flavonoids with gastroprotective effect. In this work, a flavonoid-rich fraction (Sm-FRF) obtained from scapes of S.macrolepis was investigated for preventing gastric ulceration in mice and rats.MethodsThe activity was evaluated in models of induced gastric ulcer (absolute ethanol, stress, non-steroidal anti-inflammatory drugs and pylorus ligation). The cytoprotective mechanisms of the Sm-FRF in relation to sulfhydryl (SH) groups, nitric oxide (NO) and antioxidant enzymes were also evaluated.Key findingsThe Sm-FRF (100mg/kg, p.o.) significantly reduced gastric injury in all models, and did not alter gastric juice parameters after pylorus ligation.ConclusionsThe results indicate significant gastroprotective activity for the Sm-FRF, which probably involves the participation of both SH groups and the antioxidant system. Both are integral parts of the gastrointestinal mucosa's cytoprotective mechanisms against aggressive factors.