Artículos de revistas
GENOTOXIC AND MUTAGENIC EFFECTS OF DIFLUBENZURON, AN INSECT GROWTH REGULATOR, ON MICE
Fecha
2013-09-02Registro en:
Journal Of Toxicology And Environmental Health-part A-current Issues. Philadelphia: Taylor & Francis Inc, v. 76, n. 17, p. 1003-1006, 2013.
1528-7394
10.1080/15287394.2013.830585
WOS:000326222200001
0729220781785349
Autor
Universidade Federal da Grande Dourados (UFGD)
Universidade Federal de Mato Grosso do Sul (UFMS)
Universidade Estadual Paulista (Unesp)
Institución
Resumen
This study assessed the genotoxic and mutagenic potential of diflubenzuron (DFB) insecticide in mice. Mice were divided into five groups: group I: negative control; group II: positive control; group III: 0.3 mg/kg of DFB; group IV: 1 mg/kg of DFB; group V: 3 mg/kg DFB. Peripheral blood was collected for the comet assay and the micronucleus (MN) test. DFB increased incidence of comet formation at all doses tested. A rise in the frequency of MN in mouse peripheral blood was observed 24, 48, and 72 h postexposure at all doses tested. Data demonstrate that DFB exerts genotoxic and mutagenic effects in a dose-dependent manner.