Artículos de revistas
MicroRNA Signature Obtained From the Comparison of Aggressive With Indolent Non-Hodgkin Lymphomas: Potential Prognostic Value in Mantle-Cell Lymphoma
Fecha
2013-08-10Registro en:
Journal Of Clinical Oncology. Alexandria: Amer Soc Clinical Oncology, v. 31, n. 23, p. 2903-+, 2013.
0732-183X
10.1200/JCO.2012.45.3050
WOS:000330539300015
1109525021631011
0000-0003-3775-3797
Autor
Ontario Canc Inst
Univ Toronto
Princess Margaret Hosp
Mt Sinai Hosp
Sunnybrook Hlth Sci Ctr
Univ Hlth Network
Toronto Gen Hosp
Queens Univ
Univ Alberta
British Columbia Canc Agcy
Dana Farber Canc Inst
Harvard Univ
Universidade Estadual Paulista (Unesp)
Univ Perugia
Institución
Resumen
Purpose Mantle-cell lymphoma (MCL) has a variable natural history but is incurable with current therapies. MicroRNAs (miRs) are useful in prognostic assessment of cancer. We determined an miR signature defining aggressiveness in B-cell non-Hodgkin lymphomas (NHL) and assessed whether this signature aids in MCL prognosis.MethodsWe assessed miR expression in a training set of 43 NHL cases. The miR signature was validated in 44 additional cases and examined on a training set of 119 MCL cases from four institutions in Canada. miRs significantly associated with overall survival were examined in an independent cohort of 114 MCL cases to determine association with patient outcome. miR expression was combined with current clinical prognostic factors to develop an enhanced prognostic model in patients with MCL.ResultsFourteen miRs were differentially expressed between aggressive and indolent NHL; 11 of 14 were validated in an independent set of NHL (excluding MCL). miR-127-3p and miR-615-3p were significantly associated with overall survival in the MCL training set. Their expression was validated in an independent MCL patient set. In comparison with Ki-67, expression of these miRs was more significantly associated with overall survival among patients with MCL. miR-127-3p was combined with Ki-67 to create a new prognostic model for MCL. A similar model was created with miR-615-3p and Mantle Cell Lymphoma International Prognostic Index scores.ConclusionEleven miRs are differentially expressed between aggressive and indolent NHL. Two novel miRs were associated with overall survival in MCL and were combined with clinical prognostic models to generate novel prognostic data for patients with MCL. (C) 2013 by American Society of Clinical Oncology