Artículos de revistas
Use of platelet-rich plasma in the treatment of deep corneal ulcers induced in rabbits.clinical and histomorphometric evaluation
Fecha
2013-09-03Registro en:
Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, v. 65, n. 3, p. 809-818, 2013.
0102-0935
1678-4162
10.1590/S0102-09352013000300029
S0102-09352013000300029
WOS:000322026700029
2-s2.0-84883167752
2-s2.0-84883167752.pdf
8727897080522289
0019393779801069
0000-0002-4494-4180
Autor
Faculdade de Medicina Veterinária e Zootecnia
Universidade Estadual Paulista (Unesp)
Médica veterinária autônoma
Institución
Resumen
The repair process induced corneal ulcer in rabbits using platelet-rich plasma in the form of eyedrop or clot was clinically evaluated and compared. Sixty rabbits were divided into four groups of 15 animals, denominated platelet group (PG), clot group (CLG), control group (CG), and amniotic control group (AG). Experimental groups were then subdivided into three groups (M4, M7, M30), corresponding to the end of the evaluation period. There were no differences between treatments regarding ocular sensitivity, chemosis and ocular secretion. The groups treated with PRP either as eyedrop or a clot showed less opacity than the animals treated only with amniotic membrane at the moment of the final evaluation. The presence of corneal ulcers in the groups treated with PRP showed lower intensity than the other groups. Histomorphometric examination showed that corneal epithelization in the initial phase of the lesion was greater when using PRP. The use of amniotic membrane promoted corneal epithelial and stromal thickness, as well as synergism when associated to PRP.