Artículos de revistas
Season of birth as a risk factor for multiple sclerosis in Brazil
Fecha
2013-06-15Registro en:
Journal of the Neurological Sciences, v. 329, n. 1-2, p. 6-10, 2013.
0022-510X
1878-5883
10.1016/j.jns.2013.03.001
WOS:000319086800002
2-s2.0-84876679924
Autor
Serviço de Neurologia
Universidade de São Paulo (USP)
Universidade Federal de Minas Gerais (UFMG)
Hospital da Restauração
Universidade Federal da Bahia (UFBA)
Pontifícia Universidade Católica de São Paulo (PUC-SP)
Universidade Estadual Paulista (Unesp)
Universidade Federal do Ceará (UFC)
Universidade Estadual de Londrina (UEL)
Clinica Neurológica de Joinville
Universidade Federal Fluminense (UFF)
Universidade de Taubaté
Institución
Resumen
Risk factors for development of multiple sclerosis (MS) are still a matter of debate. Latitude gradient, vitamin D deficiency and season of birth are among the most investigated environmental factors associated with the disease. Several international studies suggest that birth in spring is a substantial risk factor for MS. We investigated the season of birth as a potential risk for MS in different geographical regions of Brazil. We conducted a cross-sectional retrospective study with 2257 clinically definite MS patients enrolled in 13 Brazilian MS clinics in the south, southeast, and northeast regions of Brazil. Demographic and clinical data relating to date of birth and clinical features of the disease were collected and analysed, and subsequently compared with birth date among the general Brazilian population. The distribution of date of birth of MS patients showed an increase in spring and a decrease in autumn, with no difference being observed in the other seasons. In conclusion, season of birth is a probable risk factor for MS in most parts of Brazil. These findings may be related to the role that vitamin D plays in MS pathogenesis. © 2013 Elsevier B.V. All rights reserved.
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