Artículos de revistas
Nucleotide and phylogenetic analysis of human papillomavirus types 6 and 11 isolated from recurrent respiratory papillomatosis in Brazil
Fecha
2013-06-01Registro en:
Infection, Genetics and Evolution, v. 16, p. 282-289.
1567-1348
1567-7257
10.1016/j.meegid.2012.12.033
WOS:000320569500037
2-s2.0-84877817788
2-s2.0-84877817788.pdf
7991082362671212
0000-0001-5693-6148
Autor
Universidade Estadual Paulista (Unesp)
Universidade de São Paulo (USP)
Laboratory of Research in Virology
The Cancer Institute of the State of Sao Paulo
Santa Casa College of Medical Sciences, São Paulo
Institución
Resumen
There are few studies about the distribution of natural molecular variants of low-risk HPVs. Our aim was to evaluate the E6 early gene variability among HPV-6 and HPV-11 isolates detected in recurrent respiratory papillomatosis (RRP) samples obtained in a cohort of Brazilian patients. We also performed a phylogenetic analysis in order to compare nucleotide sequences identified in our study with previously reported isolates from different anatomic sites (laryngeal papillomas, genital warts, cervical cancer and anal swabs) obtained from other parts of the world to determine the phylogenetic relationships of variants detected in Brazil. The complete coding region of the E6 gene of 25 samples was cloned and sequenced: 18 isolates of HPV-6 (72%) and 7 isolates of HPV-11 (28%). A total of four different HPV-6 genomic variants and two HPV-11 genomic variants was identified. It was not possible to correlate specific variants with disease severity. Phylogenetic trees for both HPV types were constructed enclosing both E6 sequences detected in our study and formerly published sequences. In both phylogenetic trees, the sequences from Brazil did not group together. We could not establish a geographical association between HPV-6 or HPV-11 variants, unlike HPV-16 and HPV-18. © 2013 Elsevier B.V.
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