Artículos de revistas
Anti-inflammatory and analgesic evaluation of hydroalcoholic extract and fractions from seeds of Piper cubeba L. (Piperaceae)
Fecha
2013-05-28Registro en:
Pharmacognosy Journal, v. 5, n. 1, p. 13-16, 2013.
0975-3575
10.1016/j.phcgj.2012.12.001
2-s2.0-84878054430
4787521613038315
0000-0003-0757-7876
Autor
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
University of Mississippi
Universidade Federal de Ouro Preto (UFOP)
Universidade Estadual Paulista (Unesp)
Institución
Resumen
Some of the Piper species have been applied for the treatment of several diseases (anti-oxidant, antimicrobial, anti-inflammatory, and analgesic), considering multiple applications used in traditional medicine of different countries. About these, the present study evaluated some biological activities of Piper cubeba, as writhing test induced by acetic acid, ear edema induced by croton oil and paw edema induced by carrageenan were used by evaluated the analgesic and anti-inflammatory activities of crude hydroalcoholic extract (PCE) and its fractions of different polarities of P. cubeba L. seeds. The lethal dose (LD50) and the effective dose (ED50) were evaluated too. Both the PCE and dichloromethane fraction showed decrease values of edema and abdominal constrictions. The results obtained in this study confirm the low toxicity and analgesic and anti-inflammatory activities of PCE from P. cubeba seeds, justifying its use in folk medicine. Copyright © 2013, Phcog.Net, Published by Reed Elsevier India Pvt. Ltd. All rights reserved.