Artículos de revistas
A simple and environmentally friendly reflectometric method for the rapid quantitative analysis of captopril in pharmaceutical formulations
Fecha
2011-12-01Registro en:
Eurasian Journal of Analytical Chemistry, v. 6, n. 2, p. 91-103, 2011.
1306-3057
2-s2.0-84855173051
2-s2.0-84855173051.pdf
5978908591853524
3192125098361121
0000-0003-0197-7369
Autor
Universidade Federal do Maranhão (UFMA)
Universidade Estadual Paulista (Unesp)
Institución
Resumen
This paper describes a simple, environmentally friendly and rapid quantitative spot test procedure for the determination of captopril (CPT) in bulk drug and in pharmaceutical formulations by using diffuse reflectance spectroscopy. The proposed method is based on the reflectance measurements of the orange compound (λ max 490 nm) produced by the spot test reaction between CPT and p-chloranil (CL). Under optimal conditions, calibration curves were obtained for CPT by plotting the optical density of the reflectance signal (A R) vs. the log of the mol L -1 concentration, from 6.91×10 -3 to 1.17×10 -1, with a good coefficient of determination (R 2 = 0.9992). The common excipients used as additives in pharmaceuticals do not interfere in the proposed method. The method was applied to determine CPT in commercial pharmaceutical formulations. The results obtained by the proposed method are compared favorably with those obtained by an official procedure at 95% confidence level. The method validation results showed that the sensitivity and selectivity of the methods were adequated for drug monitoring in industrial quality control laboratories. © 2011 Moment Publication.