Artículos de revistas
Immunostimulatory effects of the phenolic compounds from lichens on nitric oxide and hydrogen peroxide production
Fecha
2009-10-01Registro en:
Brazilian Journal of Pharmacognosy, v. 19, n. 4, p. 847-852, 2009.
0102-695X
10.1590/S0102-695X2009000600009
S0102-695X2009000600009
WOS:000275593200009
2-s2.0-77949514631
2-s2.0-77949514631.pdf
3538253640602977
0000-0003-3032-2556
Autor
Universidade Estadual Paulista (Unesp)
Universidade Federal de Mato Grosso do Sul (UFMS)
Institución
Resumen
The effects of isolated compounds from Brazilian lichens and their derivatives on H 2O 2 and NO production were studied using murine macrophages as a part of an attempt to understand their possible immunomodulatory properties. The compound cytotoxicity was studied using MTT assay. Macrophage stimulation was evaluated by the determination of NO (Griess assay) and H 2O 2 (horseradish peroxidase/phenol red) in supernatants of peritoneal macrophage cultures of Swiss mice. This research demonstrated stimulatory activities of some phenolic compounds isolated from lichens and their derivatives on H 2O 2 and NO production. Structure-activity relationships suggest several synthetic directions for further improvement of immunological activity.