Artículos de revistas
Cytokine and antibody production during murine leptospirosis
Fecha
2006-11-01Registro en:
Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 12, n. 4, p. 595-603, 2006.
1678-9199
10.1590/S1678-91992006000400006
S1678-91992006000400006
WOS:000246282100006
2-s2.0-33846284154
2-s2.0-33846284154.pdf
5071093931017493
4875352337860036
2976129874554698
0810837598202634
Autor
Universidade Estadual Paulista (Unesp)
Institución
Resumen
The aim of the present study was to investigate the kinetics of humoral and cellular responses during leptospirosis. We observed that the presence of tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) was associated with antibody production and bacterial recovery, and the compromising of both TNF-α and IL-6 in the immunopathogenesis of leptospirosis during an experimental infection of BALB/c mice inoculated with Leptospira interrogans serovar Canicola was verified. Results showed higher levels of TNF-α and IL-6 in the initial phase of infection, in which the greatest bacterial clearance was observed. However, when the bacterial recovery was compared with the kinetics of the production of antibodies, the results revealed a kinetics proportionally inverted to antibody production. This fact may be related to some inhibitory factor which could be responsible for the selective suppression of the cellular immune response. We concluded that during leptospirosis there was a greater mobilization of the cellular immune response activity, mainly in the initial phase of the infectious process, for posterior involvement of the humoral response, and that both TNF-α and IL-6 could be associated with the immunopathogenesis of the disease.