dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:21:52Z
dc.date.available2014-05-27T11:21:52Z
dc.date.created2014-05-27T11:21:52Z
dc.date.issued2006-05-01
dc.identifierMedicina oral, patología oral y cirugía bucal., v. 11, n. 3, 2006.
dc.identifier1698-6946
dc.identifierhttp://hdl.handle.net/11449/68877
dc.identifier2-s2.0-33745925582
dc.identifier2-s2.0-33745925582.pdf
dc.description.abstractOBJECTIVES: Pleomorphic adenomas are the most frequent type of epithelial salivary gland neoplasms, and their malignant counterpart, the carcinoma in pleomorphic adenomas, is much less common. Beta-catenin is a cell adhesion molecule associated with the invasion and metastasis of carcinomas of the head and neck, esophagus. The objective of this study was to detect the expression of beta-catenin in pleomorphic adenomas, carcinomas in pleomorphic adenomas and normal salivary glands to discuss its role in the development of these two lesions. STUDY DESIGN: The expression of beta-catenin (BD Transduction Laboratories) was analyzed by immunohistochemistry in formalin-fixed, paraffin embedded specimens by the avidin-biotin-peroxidase complex method in 16 pleomorphic adenomas (12 from minor salivary glands), 3 carcinomas in pleomorphic adenomas (all from palate) and 10 normal salivary glands as control group (5 from major and 5 from minor salivary glands). RESULTS: All cases of glands, adenomas and carcinomas in pleomorphic adenomas have membranous and cytoplasmic immunostaining. Nuclear beta-catenin immunostaining was not observed. The antibody presented a fine granular arrangement in the cytoplasm and cellular membrane of duct and acinic cells. Higher beta-catenin index rates were seen mainly in salivary gland ducts and in ductal structures in the adenomas and carcinomas in pleomorphic adenomas. There was protein loss in pleomorphic adenomas and cytoplasmic accumulation in carcinoma in pleomorphic adenomas. CONCLUSIONS: The present study showed participation of the loss of beta-catenin adhesion molecule in the development of pleomorphic adenoma, and that the cytoplasmic accumulation of the molecule takes part in the malignant transformation of the pleomorphic adenoma into carcinoma in pleomorphic adenoma.
dc.languageeng
dc.relationMedicina Oral Patologia Oral y Cirugia Bucal
dc.relation1.671
dc.relation0,841
dc.rightsAcesso aberto
dc.sourceScopus
dc.subjectbeta catenin
dc.subjectadult
dc.subjectaged
dc.subjectbiosynthesis
dc.subjectcarcinoma
dc.subjectchild
dc.subjectfemale
dc.subjecthuman
dc.subjectimmunohistochemistry
dc.subjectmale
dc.subjectmetabolism
dc.subjectmiddle aged
dc.subjectmultiple cancer
dc.subjectpleomorphic adenoma
dc.subjectsalivary gland
dc.subjectsalivary gland tumor
dc.subjectAdenoma, Pleomorphic
dc.subjectAdult
dc.subjectAged
dc.subjectbeta Catenin
dc.subjectCarcinoma
dc.subjectChild
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNeoplasms, Multiple Primary
dc.subjectSalivary Gland Neoplasms
dc.subjectSalivary Glands
dc.titleExpression of betacatenin in carcinoma in pleomorphic adenoma, pleomorphic adenoma and normal salivary gland: an immunohistochemical study
dc.typeArtículos de revistas


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