Artículos de revistas
Evaluation of Strychnos pseudoquina St. Hil. leaves extract on gastrointestinal activity in mice
Fecha
2005-08-01Registro en:
Chemical and Pharmaceutical Bulletin, v. 53, n. 8, p. 881-885, 2005.
0009-2363
10.1248/cpb.53.881
WOS:000231320700002
2-s2.0-24944567759
3814504901386844
0000-0002-8645-3777
0000-0003-3032-2556
Autor
Universidade Estadual Paulista (Unesp)
Universidade Estadual de Campinas (UNICAMP)
Institución
Resumen
Strychnos pseudoquina St. Hil. (Loganiaceae) was investigated for its ability to protect the gastric mucosa against injuries caused by non-steroidal anti-inflammatory drugs (piroxicam) and a necrotizing agent (HCl/EtOH) in mice. The MeOH extract and enriched alkaloidic fraction (EAF) provided significant protection in experimental models wheer used at doses of 250 and 1000 mg/kg. In vivo tests were carried out to evaluate for possible toxic effects and no mortality was observed up to the 5 g/kg dose level. Phytochemical investigation led to the isolation of a new indole alkaloid, which elucidated the observed pharmacological effects. © 2005 Pharmaceutical Society of Japan.
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