Artículos de revistas
CELULOSE FIBROSA DO BAGACO DA CANA-DE-ACUCAR - AVALIACAO DA ACAO AGLUTINANTE/DESAGREGANTE EM COMPRIMIDOS CONTENDO FARMACO HIDROSSOLUVEL
Fecha
1993-12-01Registro en:
Revista de Ciencias Farmaceuticas, v. 15, p. 155-168.
0101-3793
2-s2.0-0027749940
3316011688829943
9114495952533044
5361569184579557
Autor
Universidade Estadual Paulista (Unesp)
Institución
Resumen
In this work, a fibrous cellulose obtained from the sugar cane bagasse was analysed about its binder/disintegrating action and about its interference degree in the dissolution rate ('in vitro') of active principles, when incorporated in a compact system that has a water-soluble drug. It was used as reference drug the Lithium Carbonate, considering its solubility in water and it difficulties in the compressibility and flow rate. That cellulose was evaluated in a comparative study, involving another fibrous cellulose generally used in the tablet obtainment (Microcel 3E-200). After the experiment in methodologies of dry granulation and wet granulation, it was concluded that the analysed celluloses presents adequate binder/disintegrating efficience and they are equivalents in these aspect.