Artículos de revistas
Annexin-A1 gene expression during liver development and post-translation modification after experimental endotoxemia
Fecha
2008-03-01Registro en:
Inflammation Research. Basel: Birkhauser Verlag Ag, v. 57, n. 3, p. 97-103, 2008.
1023-3830
10.1007/s00011-007-7114-2
WOS:000254436500002
5102737730539655
Autor
Universidade de São Paulo (USP)
Univ London St Bartholomews Hosp Med Coll
Univ London Imperial Coll Sci Technol & Med
Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual Paulista (Unesp)
Institución
Resumen
Objective and design: We have previously reported a role for annexin-A1 in liver proliferation and tumorogenicity as well as its action as an acute phase protein in a model of endotoxemia in interleukin-6 null mice.Material and methods: In this study, we have investigated the analysis of the gene and protein expression in annexin-A1 null mice and the wild type livers during foetal and adult life, and in the presence of a proinflammatory stimulus.Results: The data indicate a link between the expression of the annexin-A1 as serine-phosphorylated-protein during early events of the inflammatory response and as tyrosine-phosphorylated-form at later time-points, during the resolution of inflammation.Conclusions: The study of annexin-A1 post-translation modification may promote a new annexin-A1 peptide discovery programme to treat specific pathologies.