Artículos de revistas
Repeated administration intensifies the reinforcing effect of fencamfamine in rats
Fecha
1997-08-01Registro en:
General Pharmacology. Oxford: Pergamon-Elsevier B.V., v. 29, n. 2, p. 265-267, 1997.
0306-3623
10.1016/S0306-3623(96)00414-4
WOS:A1997XM42500022
2514762545280942
0000-0002-1378-6327
Autor
Universidade Estadual Paulista (Unesp)
Institución
Resumen
1. In the present study, we evaluated the role of repeated administration on conditioning place preference (CPP) induced by fencamfamine (FCF) in male rats.2. Repeated FCF (3.5 mg/kg) or saline once or daily for ten consecutive days enhanced sniffing du ration and decreased locomotion and rearing duration.3. At the 3.5 mg/kg dose, FCF produced a significant place-preference effect.4. Repeated exposures to FCF intensified its reinforcing properties.5. These results suggest that repeated FCF administration sensitizes its rewarding effects, as with other addictive substances. GEN PHARMAC 29;2:265-261, 1997. (C) 1997 Elsevier B.V.