Artículos de revistas
Antiplasmodial activity of aryltetralone lignans from Holostylis reniformis
Fecha
2007-07-01Registro en:
Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 51, n. 7, p. 2346-2350, 2007.
0066-4804
10.1128/AAC.01344-06
WOS:000247665800008
WOS000247665800008.pdf
Autor
Universidade Estadual Paulista (Unesp)
Fiocruz MS
Universidade Federal de Minas Gerais (UFMG)
Univ Nova Lisboa
Institución
Resumen
Extracts from Holostylis reniformis were tested in vivo against Plasmodium berghei and in vitro against a chloroquine-resistant strain of Plasmodium falciparum. The hexane extract of the roots was the most active, causing 67% reduction of parasitemia in vivo. From this extract, six lignans, including a new (7 ' R,8S,8 ' S)-3 ',4 '-methylenedioxy-4,5-dimethoxy-2,7 '-cyclolignan-7-one, were isolated and tested in vitro against P. falciparum. The three most active lignans showed 50% inhibitor concentrations of <= 0.32 mu M. An evaluation of minimum lethal dose (30%) values showed low toxicity for these lignans in a hepatic cell line (Hep G2A16). Therefore, these compounds are potential candidates for the development of antimalarial drugs.