Artículos de revistas
VCD to determine absolute configuration of natural product molecules: secolignans from Peperomia blanda
Fecha
2012-01-01Registro en:
Organic & Biomolecular Chemistry. Cambridge: Royal Soc Chemistry, v. 10, n. 21, p. 4208-4214, 2012.
1477-0520
10.1039/c2ob25109d
WOS:000303768700008
0124211071790021
1308042794786872
Autor
Universidade Estadual Paulista (Unesp)
Universidade Estadual de Maringá (UEM)
Universidade de São Paulo (USP)
BioTools Inc
Syracuse Univ
Institución
Resumen
The absolute configuration and solution-state conformers of three peperomin-type secolignans isolated from Peperomia blanda (Piperaceae) are unambiguously determined by using vibrational circular dichroism (VCD) spectroscopy associated with density functional theory (DFT) calculations. Advantages of VCD over the electronic form of CD for the analysis of diastereomers are also discussed. This work extends our growing knowledge about secondary metabolites within the Piperaceae family species while providing a definitive and straightforward method to assess the absolute stereochemistry of secolignans.