Artículos de revistas
Molecular physicochemical parameters predicting antioxidant activity of Brazilian natural products
Fecha
2009-10-01Registro en:
Revista Brasileira de Farmacognosia-brazilian Journal of Pharmacognosy. Amsterdam: John Benjamins Publishing Company, v. 19, n. 4, p. 908-913, 2009.
0102-695X
S0102-695X2009000600020
WOS:000275593200020
S0102-695X2009000600020.pdf
4484083685251673
Autor
Universidade de São Paulo (USP)
Universidade Federal da Paraíba (UFPB)
Universidade Estadual Paulista (Unesp)
Institución
Resumen
Reactive oxygen species (ROS) are capable of oxidizing cellular proteins, nucleic acids and lipids, contributing to cellular aging, mutagenesis, carcinogenesis, coronary heart and neurodegenerative diseases. Free radicals-scavenging by phenolic compounds occurs by the transfer of one electron followed by the H-abstraction. In order to evaluate the antioxidant activity of a series of seventeen phenolic compounds extracted from Brazilian flora (Chimarrhis turbinata and Arrabidea samydoides), some physicochemical parameters (heat formation of the neutral, radical, and cationic compounds; orbitals' energies; ClogP;Delta H(OX); and Delta H(f)) were calculated. Considering the results from the calculated descriptors, the molecules 10a-f can be classified as having a higher antioxidant activity.