Artículos de revistas
Photodynamic therapy for the treatment of buccal candidiasis in rats
Fecha
2009-11-01Registro en:
Lasers In Medical Science. Artington: Springer London Ltd, v. 24, n. 6, p. 877-884, 2009.
0268-8921
10.1007/s10103-009-0673-4
WOS:000270894900006
0322020541055900
0053567153623569
Autor
Universidade Estadual Paulista (Unesp)
Universidade de Taubaté (UNITAU)
Institución
Resumen
The study objective was to evaluate the effects of photodynamic therapy on buccal candidiasis in rats. After experimental candidiasis had been induced on the tongue dorsum, 72 rats were distributed into four groups according to treatment: treated with laser and methylene blue photosensitizer (L+P+); treated only with laser (L+P-); treated only with photosensitizer (L--P+); not treated with laser or photosensitizer (L-P-). The rats were killed immediately, 1 day, or 5 days after treatment, for microscopic analysis of the tongue dorsum. Observation verified that the photodynamic therapy group (L+P+) exhibited fewer epithelial alterations and a lower chronic inflammatory response than the L-P- group. The group L+P- presented more intense epithelial alterations and chronic inflammatory response than the remaining groups. The L-P+ group showed tissue lesions similar to those of the L-P- group. In conclusion, rats treated with photodynamic therapy developed more discrete candidiasis lesions than did the remaining groups.