Artículos de revistas
Effects of fluoride intake on insulin sensitivity and insulin signal transduction
Date
2008-10-01Registration in:
Fluoride. Ocean View: Int Soc Fluoride Research, v. 41, n. 4, p. 270-275, 2008.
0015-4725
WOS:000263901900003
7239471016654133
8275401688702343
4419158525709686
0000-0001-5069-8812
Author
Universidade Estadual Paulista (Unesp)
Institutions
Abstract
Forty seven-week-old male castrated Wistar rats were randomly divided evenly into a control group and a fluoride (F) group. The latter was given a single dose of NaF from a solution containing 1.0 mg F ion/kg bw, administered by gavage. After 30 min, the following experiments were performed: intravenous insulin tolerance test (0.75 U/kg bw) and determination of the insulin receptor substrate (pp 185-IRS-1/IRS/2) tyrosine phosphorylation status. The acute treatment with NaF promoted increased blood glycemia, but there were no significant changes in the insulin sensitivity and in the pp185 tyrosine phosphorylation status in the muscular or in the white adipose tissues.
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