Acute bacterial cystitis does not cause deoxyribonucleic acid damage detectable by the alkaline comet assay in urothelial cells of dogs

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:39:19Z
dc.date.available2014-05-20T13:39:19Z
dc.date.created2014-05-20T13:39:19Z
dc.date.issued2004-05-01
dc.identifierVeterinary Pathology. Lawrence: Amer Coll Vet Pathologist, v. 41, n. 3, p. 299-301, 2004.
dc.identifier0300-9858
dc.identifierhttp://hdl.handle.net/11449/13646
dc.identifier10.1354/vp.41-3-299
dc.identifierWOS:000221344700018
dc.identifier6077735918469284
dc.identifier0000-0002-8188-8149
dc.description.abstractConsidering the high incidence of dogs with acute bacterial cystitis (BC) and the relationship among inflammation, genotoxicity, and carcinogenesis, we conducted a case-control study comparing the frequency of deoxyribonucleic acid (DNA) lesions assessed by the comet assay between disease-free animals (13 males and 13 females) and cytology-confirmed cases of acute BC (12 males and 12 females), which was mainly caused by Staphylococcus sp. (40%) and Escherichia coli (35%). The results show no increase in DNA damage in cells obtained by bladder washings and no influence of age, sex, and breed due to acute BC. In conclusion, DNA damage was seemingly not associated with the infection by specific bacteria.
dc.languageeng
dc.publisherAmer Coll Vet Pathologist
dc.relationVeterinary Pathology
dc.relation1.795
dc.relation1,078
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.titleAcute bacterial cystitis does not cause deoxyribonucleic acid damage detectable by the alkaline comet assay in urothelial cells of dogs
dc.typeArtículos de revistas


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