Artículos de revistas
Genotoxicity of antimicrobial endodontic compounds by single cell gel (comet) assay in Chinese hamster ovary (CHO) cells
Fecha
2005-05-01Registro en:
Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics. St Louis: Mosby, Inc., v. 99, n. 5, p. 637-640, 2005.
1079-2104
10.1016/j.tripleo.2004.07.010
WOS:000228655300022
5051118752980903
Autor
Universidade Estadual Paulista (Unesp)
Institución
Resumen
Objective. In the current study, the potential DNA damage associated with exposure to a number of antimicrobial endodontic compounds was assessed by the single cell gel (comet) assay in vitro.Study design. Chinese hamster ovary (CHO) cells were exposed to formocresol, paramonochlorophenol, calcium hydroxide, or chlorhexidine at final concentration ranging from 0.01% to 1%.Results. Formocresol, paramonochlorophenol, and calcium hydroxide, as well as chlorhexidine in all concentrations tested did not contribute to the DNA damage.Conclusion. These findings are clinically relevant since they represent an important contribution to the correct evaluation of the potential health risk associated with exposure to dental agents.