Artículos de revistas
Assessment of the potential genotoxic risk of medicinal Tamarindus indica fruit pulp extract using in vivo assays
Fecha
2009-01-01Registro en:
Genetics and Molecular Research. Ribeirao Preto: Funpec-editora, v. 8, n. 3, p. 1085-1092, 2009.
1676-5680
10.4238/vol8-3gmr630
WOS:000272050000016
WOS000272050000016.pdf
4787521613038315
0000-0003-0757-7876
Autor
Universidade Estadual Paulista (Unesp)
Univ Jose do Rosario Vellano
Universidade de São Paulo (USP)
Institución
Resumen
Tamarindus indica has been used in folk medicine as an antidiabetic, a digestive aid, and a carminative, among other uses. Currently, there is no information in the toxicology literature concerning the safety of T. indica extract. We evaluated the clastogenic and/or genotoxic potential of fruit pulp extract of this plant in vivo in peripheral blood and liver cells of Wistar rats, using the comet assay, and in bone marrow cells of Swiss mice, using the micronucleus test. The extract was administered by gavage at doses of 1000, 1500 and 2000 mg/kg body weight. Peripheral blood and liver cells from Wistar rats were collected 24 h after treatment, for the comet assay. The micronucleus test was carried out in bone marrow cells from Swiss mice collected 24 h after treatment. The extract made with T. indica was devoid of clastogenic and genotoxic activities in the cells of the rodents, when administered orally at these three acute doses.