Artículos de revistas
Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae)
Fecha
2009-01-01Registro en:
Química Nova. Sociedade Brasileira de Química, v. 32, n. 5, p. 1222-1226, 2009.
0100-4042
10.1590/S0100-40422009000500026
S0100-40422009000500026
WOS:000269124800026
S0100-40422009000500026.pdf
2114570774349859
0000-0003-3032-2556
Autor
Universidade Estadual Paulista (Unesp)
Universidade Federal de Mato Grosso do Sul (UFMS)
Instituto Adolfo Lutz (IAL)
Institución
Resumen
The anti-Mycobacterium tuberculosis activity of Campomanesia adamantium fruits extracts were evaluated. Six compounds, identified as flavanones and chalcones were quantified by HPLC-DAD-UV. Promising antitubercular activity was observed with ethyl acetate extract (MIC 62.5 µg/mL) and their fractions (MIC values ranging from 39 to above 250 µg/mL). The better MIC result of 39 µg/mL was associated with two fractions that contain bigger amounts of 5,7-dihydroxy-6, 8-di-C-methylflavanone and 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone. These compounds exhibited MICs >250 and 62.5 µg/mL, respectively, while their mixtures showed values ranging from 62.5 to 7.8 µg/mL, demonstrating a synergism between them.