Development and validation of a nonaqueous titration with perchloric acid to determine sparfloxacin in tablets

Artículos de revistas

Fecha

2001-09-01

Registro en:

European Journal of Pharmaceutics and Biopharmaceutics. Amsterdam: Elsevier B.V., v. 52, n. 2, p. 227-229, 2001.

0939-6411

http://hdl.handle.net/11449/7608

10.1016/S0939-6411(01)00177-1

WOS:000171259000017

Autor

Universidade Estadual Paulista (Unesp)

Universidade Federal do Rio Grande do Sul (UFRGS)

Institución

Universidade Estadual Paulista (Brasil)

Resumen

A simple, rapid and inexpensive method for the determination of sparfloxacin in tablets is described. The procedure is based on the use of volumetric dosage in a nonaqueous medium in glacial acetic acid with 0.1 M perchloric acid. The method validation yielded good results and included precision and accuracy. It was also found that the excipients in the commercial tablet preparation did not interfere with the assay. (C) 2001 Elsevier B.V. B.V. All rights reserved.

Materias

fluoroquinolone

nonaqueous titration

pharmaceutical analysis

sparfloxacin

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