Synthesis of potentially bioactive PABA-related N-(aminoalkyl)lactamic amino acids and esters via selective SNAr reactions

Brasil | Artículos de revistas

Fecha

2011-01-01

Registro en:

Amino Acids. New York: Springer, v. 40, n. 1, p. 197-204, 2011.

0939-4451

http://hdl.handle.net/11449/6863

10.1007/s00726-010-0634-z

WOS:000285781000018

Autor

Universidade Estadual Paulista (Unesp)

Universidade Estadual de Campinas (UNICAMP)

Institución

Universidade Estadual Paulista (Brasil)

Resumen

Potentially bioactive N-(aminoalkyl)lactamic amino acids and esters were synthesized in satisfactory to good yields by SNAr reactions of aromatic acids with N-(3-aminopropyl)lactams followed by esterification with tertiary amino alcohols. The addition-elimination SNAr mechanism was confirmed by NMR and MS measurements.

Materias

PABA derivatives

Lactams

Potential bio-activity

SNAr reaction

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