Artículos de revistas
Effects of Low Molecular Weight Sulfated Galactan Fragments From Botryocladia Occidentalis on the Pharmacological and Enzymatic Activity of Spla2 From Crotalus Durissus Cascavella
Fecha
2010-11-01Registro en:
Protein Journal. New York: Springer, v. 29, n. 8, p. 567-571, 2010.
1572-3887
10.1007/s10930-010-9294-9
WOS:000284644400005
8573195327542061
Autor
Universidade Estadual Paulista (Unesp)
Univ Presbiteriana Mackenzie
Universidade Federal do Ceará (UFC)
Universidade Federal do Rio de Janeiro (UFRJ)
Universidade Estadual de Campinas (UNICAMP)
UFC
Institución
Resumen
Low molecular weight fragments of sulfated galactans (Boc-5 and Boc-10) from the red algae Botryocladia occidentalis significantly inhibited Crotalus durissus cascavella sPLA2 enzymatic activity. Equimolar ratios of sPLA2 to Boc-5 or Boc-10 resulted in allosteric inhibition of sPLA2. Under the conditions tested, we observed that both Boc-5 and Boc-10 strongly decreased edema, myonecrosis, and neurotoxicity induced by native sPLA2.