Effects of Low Molecular Weight Sulfated Galactan Fragments From Botryocladia Occidentalis on the Pharmacological and Enzymatic Activity of Spla2 From Crotalus Durissus Cascavella

Artículos de revistas

Date

2010-11-01

Registration in:

Protein Journal. New York: Springer, v. 29, n. 8, p. 567-571, 2010.

1572-3887

http://hdl.handle.net/11449/336

10.1007/s10930-010-9294-9

WOS:000284644400005

8573195327542061

http://repositorioslatinoamericanos.uchile.cl/handle/2250/2516561

Author

Universidade Estadual Paulista (UNESP)

Univ Presbiteriana Mackenzie

Universidade Federal do Ceará (UFC)

Universidade Federal do Rio de Janeiro (UFRJ)

Universidade Estadual de Campinas (UNICAMP)

UFC

Institutions

Universidade Estadual Paulista (Brasil)

Abstract

Low molecular weight fragments of sulfated galactans (Boc-5 and Boc-10) from the red algae Botryocladia occidentalis significantly inhibited Crotalus durissus cascavella sPLA2 enzymatic activity. Equimolar ratios of sPLA2 to Boc-5 or Boc-10 resulted in allosteric inhibition of sPLA2. Under the conditions tested, we observed that both Boc-5 and Boc-10 strongly decreased edema, myonecrosis, and neurotoxicity induced by native sPLA2.

Subjects

Botryocladia occidentalis

Crotalus durissus cascavella

Secretory phospholipase A2 (sPLA2)

Edema

Myonecrosis

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