Artículos de revistas
Immunoexpression of E-cadherin and vimentin in normal oral mucosa, oral epithelial displasia and oral squamous cell carcinoma Inmunoexpresión de E-cadherina y vimentina en mucosa oral normal, displasia epitelial oral y carcinoma oral de células escamosas
Fecha
2017Registro en:
International Journal of Morphology, Volumen 35, Issue 2, 2018, Pages 596-602
07179502
07179367
10.4067/S0717-95022017000200035
Autor
Santibáñez, Natalia
Fernández, Alejandra
Fernández, Javier
Villacura Martínez, René Armando
Fawaz, Juan Pablo
Olate, Sergio
Haidar, Ziyad S.
Institución
Resumen
© 2017, Universidad de la Frontera. All rights reserved. The aim was to evaluate the expression of E-cadherin and Vimentin in oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC), in comparison with normal oral mucosa (NOM) in a descriptive case study using immunohistochemistry. A total of fifty-one (N=51) histological samples were included; as follows: n = 16 (NOM), n = 16 (OED) and n = 19 (OSCC). All samples were analyzed using immunohistochemistry against the expression of E-cadherin and Vimentin. Immunostaining was qualitatively evaluated by extent and intensity of its expression for E-cadherin and intensity for Vimentin. Extension and intensity analysis of E-cadherin and Vimentin immunostaining according to group revealed a statistically significant association (r<0.001). E-cadherin expression was found to be highest in NOM followed by OED and lowest in OSCC, inverse to what was observed with Vimentin. The present study revealed the down regulation of the molecu