Artículo de revista
Early discoid lupus erythematosus protects against renal disease in patients with systemic lupus erythematosus: Longitudinal data from a large Latin American cohort
Lupus, Volumen 26, Issue 1, 2018, Pages 73-83
Pons Estel, Guillermo
Aspey, L. D.
Pons-Estel, Bernardo A.
Haye Salinas, M. J.
Sato, E. I.
Soriano, E. R.
Costallat, L. T.L.
Iglesias Gamarra, Antonio J.
Gil Reyes, Llerena
Cardiel, M. H.
Acevedo Vásquez, Eduardo
© SAGE Publications. Objectives The objective of this study was to examine whether early discoid lupus erythematosus (DLE) would be a protective factor for further lupus nephritis in patients with systemic lupus erythematosus (SLE). Methods We studied SLE patients from GLADEL, an inception longitudinal cohort from nine Latin American countries. The main predictor was DLE onset, which was defined as physician-documented DLE at SLE diagnosis. The outcome was time from the diagnosis of SLE to new lupus nephritis. Univariate and multivariate survival analyses were conducted to examine the association of DLE onset with time to lupus nephritis. Results Among 845 GLADEL patients, 204 (24.1%) developed lupus nephritis after SLE diagnosis. Of them, 10 (4.9%) had DLE onset, compared to 83 (12.9%) in the group of 641 patients that remained free of lupus nephritis (hazard ratio 0.39; P = 0.0033). The cumulative proportion of lupus nephritis at 1 and 5 years since SLE diagnosis was 6% and 14%, resp
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First Latin American clinical practice guidelines for the treatment of systemic lupus erythematosus: Latin American Group for the Study of Lupus (GLADEL, Grupo Latino Americano de Estudio del Lupus)-Pan-American League of Associations of Rheumatology (PAN Pons-Estel, Bernardo A.; Bonfa, Eloisa; Soriano, Enrique R.; Cardiel, Mario H.; Izcovich, Ariel; Popoff, Federico; Criniti, Juan M.; Vásquez, Gloria; Massardo, Loreto; Duarte, Margarita; Barile-Fabris, Leonor A.; García, Mercedes A.; Amigo, Mary Carmen; Espada, Gracie (BMJ Publishing Group, 2018)© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Systemic lupus erythematosus (SLE), a complex and heterogeneous autoimmune ...
First Latin American clinical practice guidelines for the treatment of systemic lupus erythematosus: Latin American Group for the Study of Lupus (GLADEL, Grupo Latino Americano de Estudio del Lupus)-Pan-American League of Associations of Rheumatology (PANLAR) Unknown author (BMJ Publishing Group, 2018)Systemic lupus erythematosus (SLE), a complex and heterogeneous autoimmune disease, represents a significant challenge for both diagnosis and treatment. Patients with SLE in Latin America face special problems that should ...
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