Artículo de revista
Hindsight regulates photoreceptor axon targeting through transcriptional control of jitterbug/Filamin and multiple genes involved in axon guidance in Drosophila
Fecha
2015Registro en:
Developmental Neurobiology, Volumen 75, Issue 9, 2018, Pages 1018-1032
1932846X
19328451
10.1002/dneu.22271
Autor
Oliva, Carlos
Molina-Fernandez, Claudia
Maureira, Miguel
Candia, Noemi
López, Estefanía
Hassan, Bassem
Aerts, Stein
Cánovas, José
Olguín, Patricio
Sierralta, Jimena
Institución
Resumen
© 2015 Wiley Periodicals, Inc.During axon targeting, a stereotyped pattern of connectivity is achieved by the integration of intrinsic genetic programs and the response to extrinsic long and short-range directional cues. How this coordination occurs is the subject of intense study. Transcription factors play a central role due to their ability to regulate the expression of multiple genes required to sense and respond to these cues during development. Here we show that the transcription factor HNT regulates layer-specific photoreceptor axon targeting in Drosophila through transcriptional control of jbug/Filamin and multiple genes involved in axon guidance and cytoskeleton organization.Using a microarray analysis we identified 235 genes whose expression levels were changed by HNT overexpression in the eye primordia. We analyzed nine candidate genes involved in cytoskeleton regulation and axon guidance, six of which displayed significantly altered gene expression levels in hnt mutant reti