Artículos de revistas
Large contribution of human papillomavirus in vaginal neoplastic lesions: A worldwide study in 597 samples
Fecha
2014Registro en:
European Journal of Cancer, Volumen 50, Issue 16, 2018, Pages 2846-2854
18790852
09598049
10.1016/j.ejca.2014.07.018
Autor
Alemany, L.
Saunier, M.
Tinoco, L.
Quirós B., Paula
Alvarado-Cabrero, I.
Alejo, M.
Joura, E. A.
Maldonado, P.
Klaustermeier, J.
Salmerón, J.
Bergeron, C.
Petry, K. U.
Guimerà, N.
Clavero, O.
Murillo, R.
Clavel, C.
Wain, V.
Geraets, D. T.
Jach, R.
Cross, P.
Carr, David
Institución
Resumen
© 2014 Elsevier Ltd.This work describes the human papillomavirus (HPV) prevalence and the HPV type distribution in a large series of vaginal intraepithelial neoplasia (VAIN) grades 2/3 and vaginal cancer worldwide. Methods We analysed 189 VAIN 2/3 and 408 invasive vaginal cancer cases collected from 31 countries from 1986 to 2011. After histopathological evaluation of sectioned formalin-fixed paraffin-embedded samples, HPV DNA detection and typing was performed using the SPF-10/DNA enzyme immunoassay (DEIA)/LiPA25 system (version 1). A subset of 146 vaginal cancers was tested for p16INK4a expression, a cellular surrogate marker for HPV transformation. Prevalence ratios were estimated using multivariate Poisson regression with robust variance. Results HPV DNA was detected in 74% (95% confidence interval (CI): 70-78%) of invasive cancers and in 96% (95% CI: 92-98%) of VAIN 2/3. Among cancers, the highest detection rates were observed in warty-basaloid subtype of squamous cell carcinomas,