Artículo de revista
Factores de riesgo de ocurrencia y gravedad de malformaciones congénitas
Fecha
2014Registro en:
Rev Med Chile 2014; 142: 1431-1439
07176163
00349887
10.4067/S0034-98872014001100010
Autor
Canals Cifuentes, Andrea
Cavada Chacón, Gabriel
Nazer Herrera, Julio
Institución
Resumen
Background: The relative importance of congenital malformations as a cause
of death in the first year of life is increasing along with the control of preventable
causes of perinatal mortality. Aim: To identify risk factors for congenital malformations. Patients and Methods: Retrospective case-control study of births
registered in the database of The Latin American Collaborative Study of Congenital Malformations (ECLAMC), in the period 2001-2010. Results: Birth weight
and gestational age were significantly lower in cases than controls, behaving as
risk factors and associated with a greater severity of congenital malformations.
The risk and severity of congenital malformations increased along with mother’s
age. Fetal growth retardation, a history of congenital malformations in the
family, physical factors and acute illnesses of the mother in the first trimester of
pregnancy were also significant risk factors for congenital malformations and
their severity. The educational level of the mother was a protective factor for
congenital malformations and their severity. Conclusions: Variables previously
identified as risk factors for congenital malformations, were significantly related
with the occurrence of congenital malformations and their severity.