Artículo de revista
Gene expression in superior temporal cortex of schizophrenia patients
Fecha
2014Registro en:
European Archives of Psychiatry and Clinical Neuroscience, Volumen 264, Issue 4, 2018, Pages 297-309
14338491
09401334
10.1007/s00406-013-0473-5
Autor
Sellmann, C.
Pildaín, L. Villarín
Schmitt, A.
Leonardi-Essmann, F.
Durrenberger, P. F.
Spanagel, R.
Arzberger, T.
Kretzschmar, H.
Zink, M.
Gruber, O.
Herrera-Marschitz Muller, Mario
Reynolds, R.
Falkai, P.
Gebicke-Haerter, P. J.
Matthäus, F.
Institución
Resumen
We investigated gene expression pattern obtained from microarray data of 10 schizophrenia patients and 10 control subjects. Brain tissue samples were obtained postmortem; thus, the different ages of the patients at death also allowed a study of the dynamic behavior of the expression patterns over a time frame of many years. We used statistical tests and dimensionality reduction methods to characterize the subset of genes differentially expressed in the two groups. A set of 10 genes were significantly downregulated, and a larger set of 40 genes were upregulated in the schizophrenia patients. Interestingly, the set of upregulated genes includes a large number of genes associated with gene transcription (zinc finger proteins and histone methylation) and apoptosis. We furthermore identified genes with a significant trend correlating with age in the control (MLL3) or the schizophrenia group (SOX5, CTRL). Assessments of correlations of other genes with the disorder (RRM1) or with the duratio