Artículos de revistas
Metabolic effect of metformin in obese adolescents at risk of diabetes mellitus type 2 Efecto metabólico de la metformina en adolescentes obesas con riesgo de diabetes mellitus tipo 2
Fecha
2012Registro en:
Revista Chilena de Pediatria, Volumen 83, Issue 1, 2018, Pages 48-57
03704106
07176228
10.4067/S0370-41062012000100006
Autor
Bernardita Prado, Alcalde
Verónica Gaete, P.
Francisca Corona, H.
Eldreth Peralta, V.
Paula Donoso, A.
Ximena Raimann, T.
Institución
Resumen
In adults, metformin promotes weight loss and prevents the development of type 2 diabetes mellitus (DM2). However, these effects have not been demonstrated in adolescents at risk for DM2. Objective: To analyze the anthropometric and metabolic impact of metformin in obese adolescents at risk for DM2. Patients and Methods: A double-blind, placebo-controlled study was conducted in 19 obese female adolescents at risk for DM2. A structured lifestyle intervention with nutritional and exercise education and motivational support was assessed over 3 month with an additional follow up period of 3 months. Subjects were randomized to 500 mg/ daily of extended release metformin or placebo. Anthropometric (weight, BMI, waist circumference, blood pressure) and metabolic profiles (glycemia, HOMA, lipid profile, AST, ALT) were compared between both groups at the end of both periods. Results: Metformin treated group showed a significant reduction in weight and body mass index (BMI) compared with placebo