Acanthosis nigricans as an indicator of insulin resistance in Chilean adult population Acantosis nigricans como un indicador deinsulinoresistencia en poblacion Chilena adulta

Abstract

Background: Insulin resistance (IR) is associated with a higher risk of multiple diseases and its early detection would allow to minimize the associated risk; the presence of acanthosis nigricans (AN) it's associated to the presence of IR. Objective: To evaluate the sensibility and specificity of AN to diagnose IR in a group of Chilean patients. Methods: We designed a cross-sectional study and it was included subjects that were attended at the Center for the Attention of Metabolic Diseases at the Faculty of Medicine, University of Chile. Sixty subjects (18-60 years age) were included. It was determined BMI and diagnosed AN and skin phototype; blood samples were taken and calculated the HOMA-IR. The normality of the variables where analyzed by Kolmogorov-Smirnov test. There were used x 2 and the diagnostic concordance between AN and IR was determined using the Kappa index and Pearson's correlation. Sensibility, specificity, positive and negative predictive value were calculated and acce