Artículo de revista
High prevalence of specific language impairment in Robinson Crusoe Island. A possible founder effect Alta prevalencia de trastorno específico de lenguaje en isla Robinson Crusoe y probable efecto fundador
Revista Medica de Chile, Volumen 136, Issue 2, 2018, Pages 186-192
Villanueva Bianchini, Pía
Barbieri Ortiz, Zulema de,
Palomino, Hernán M.
Background: Specific language impairment (SLI) occurs in 2% to 8% of preschool children. Major and candidate genes are probably involved. Genetic drift is a cause for the presence of high frequencies of deleterious alleles of a specific disease and the founder effect is one of its forms. Robinson Crusoe Island has 633 inhabitants and its actual population began with 8 families that repopulated the island at the end of XIXth century. Aim: To assess the frequency of specific language impairment among children living in Robinson Crusoe Island. Material and methods: All 66 children aged between 3 and 9 years living in the island, were studied. Parents were interviewed and in children, non verbal intelligence, audiometric parameters, comprehension and expression of oral language were assessed. Extended genealogies were also performed. Results: Forty children had at least one parent that was descending of founder families. Among these, 35% had SLI. Eighth five percent of SLI affected childre