Artículos de revistas
Early metabolic derangements in daughters of women with polycystic ovary syndrome
Fecha
2007Registro en:
Journal of Clinical Endocrinology and Metabolism, Volumen 92, Issue 12, 2018, Pages 4637-4642
0021972X
0021972X
10.1210/jc.2007-1036
Autor
Sir Petermann, Teresa
Maliqueo Yevilao, Manuel
Codner Dujovne, Ethel
Echiburú López, Bárbara
Crisosto King, Nicolás
Pérez, Virginia
Pérez Bravo, Francisco
Cassorla Goluboff, Fernando
Institución
Resumen
Context: Polycystic ovary syndrome (PCOS) is a familial endocrine-metabolic dysfunction, increasingly recognized in adolescent girls with hyperandrogenism. However, it is difficult to establish whether the metabolic abnormalities described in PCOS are present before the onset of hyperandrogenism. In children, a strong association of adiponectin levels with metabolic parameters of insulin resistance has been described. Objective: The objective of the study was to evaluate adiponectin serum concentrations and metabolic parameters in prepubertal and pubertal daughters of women with PCOS to identify girls with increased metabolic risk. Design: Fifty-three prepubertal and 22 pubertal (Tanner stages II-V) daughters of PCOS women (PCOSd) and 32 prepubertal and 17 pubertal daughters of control women (Cd) were studied. In both groups, an oral glucose tolerance test was performed with measurement of glucose and insulin. Adiponectin, leptin, C-reactive protein, SHBG, sex steroids, and lipids were