Artículos de revistas
The CK1 gene family: Expression patterning in zebrafish development
Fecha
2007Registro en:
Biological Research, Volumen 40, Issue 2, 2018, Pages 251-266
07176287
07169760
10.4067/S0716-97602007000200015
Autor
Albornoz, Amelina
Yáñez López, José
Foerster, Claudia
Aguirre, Celeste
Pereiro, Luisa
Burzio, Verónica
Moraga, Mauricio
Reyes, Ariel E.
Antonelli, Marcelo
Institución
Resumen
Protein kinase CK1 is a ser/thr protein kinase family which has been identified in the cytosol cell fraction, associated with membranes as well as in the nucleus. Several isoforms of this gene family have been described in various organisms: CK1α, CK1β, CK1δ, CK1̇and CK1γ. Over the last decade, several members of this family have been involved in development processes related to wnt and sonic hedgehog signalling pathways. However, there is no detailed temporal information on the CK1 family in embryonic stages, even though orthologous genes have been described in several different vertebrate species. In this study, we describe for the first time the cloning and detailed expression pattern of five CK1 zebrafish genes. Sequence analysis revealed that zebrafish CK1 proteins are highly homologous to other vertebrate orthologues. Zebrafish CK1 genes are expressed throughout development in common and different territories. All the genes studied in development show maternal and zygotic express